Neurological outcomes in immune checkpoint
While the spectrum of neurological immune checkpoint inhibitor-related adverse events is expanding, patients’ outcomes are not well documented. This study aimed to assess outcomes of neurological immune-related adverse events and to identify prognostic factors. All patients experiencing grade ≥2 neurological immune-related adverse events identified at two clinical networks (French Reference Center for Paraneoplastic Neurological Syndromes, Lyon; and OncoNeuroTox, Paris) over five years were included.
The present data showed that neurological recovery in n-irAE patients depends on the baseline characteristics and the type of clinical presentation and that myositis/NMJ disorders and melanoma are associated with a higher probability of improvement, while older age and paraneoplastic-like syndromes are associated with lower chances of neurological recovery. Future studies are needed to optimize the management of such patients.
