A Pilot Study to Develop Paraneoplastic Cerebellar
An animal model of paraneoplastic cerebellar degeneration (PCD) would be useful to decipher the immune mechanisms leading to the neurological damages observed in this disease, particularly those associated with anti-Yo antibodies (Yo-PCD), which are the most frequent [1]. In patients, it is near impossible to analyze the pathological mechanisms leading to Purkinje cell death because of the lack of cerebellum pathology at the early stage of the disease. Moreover, only a few post-mortem analyses are available; they are performed late after the onset of the immune process when most, if not all, Purkinje cells have been eliminated.
