New publications of BETPSY
October 2024: PNS Associated With Merkel Cell Carcinoma
Ciano-Peterson et al. describe the clinical and immunologic profile of patients with paraneoplastic neurologic syndromes associated with Merkel cell carcinoma.
July 2024 - Article: Diagnostic and prognostic biomarkers in immune checkpoint...
Farina et al. aimed to comprehensively characterise ICI-encephalitis and identify diagnostic biomarkers and outcome predictors.
July 2024 - Article: Opsoclonus-Ataxia Syndrome in a Patient With
Farina et al. describe a case of post-immune checkpoint inhibitor (ICI) opsoclonus-myoclonus-ataxia syndrome (OMAS), with complete clinical remission after treatment.
July 2024 - Article: HLA-DR3 ~ DQ2 associates with sensory neuropathy...
Muñiz-Castrillo et al onducted an HLA association analysis in a large cohort of anti-Hu PNS,exploring potential diferences according to clinical presentation and cancer status.
May 2024 - Article: Predictors and Clinical Characteristics...
Campetella et al. clinically characterized the relapses and identified factors predicting their occurrence in patients with anti-LGI1 antibodies.
April 2024 - Article: Comparative Study of ....
Lamblin et al. aime to compare the clinical presentation, immunogenetic characteristics,and neurologic outcome of paraneoplastic and nonparaneoplastic GABABR-AE identified in the French and the Dutch Paraneoplastic Neurologic Syndromes Reference Centers between 2011 and 2022
November 2023 - Article: Peripheral nervous system...
Theuriet et al. aimed to study PNS symptoms in patients with CSF GFAP-Abs.
September 2023 - Article: Revisiting anti-Hu...
Villagran et al evaluate the combination of neurological phenotypes in a large retrospective cohort of anti-Hu PNS and describe the diagnostic workflow to detect a cancer. Additionally, they investigated the outcome according to different clinical aspects and took a closer look at patients without a detectable malignancy after a long follow-up.
August 2023 - Article: Different Genetic Signatures of SCLC...
Vogrig et al. clarify whether the genomic and transcriptomic features of SCLC are different in patients with anti-GABABR or anti-Hu PNS compared with SCLC without PNS.
August 2023 - Article: Trigeminal Nerve Involvement...
Cluse et al report 2 cases of atypical trigeminal neuropathy in bulbar-onset IgLON5-D.
May 2023 - Article: Neurological outcomes in...
Farina et al. assess outcomes of neurological immune-related adverse events and to identify prognostic factors
Februrary 2023 - Article: A Pilot Study to Develop PCD mouse model
Faure et al. present a pilot study aiming at modeling paraneoplastic cerebellar degeneration with Yo autoantibodies (Yo-PCD)
September 2022 - Article: Paraneoplastic neurological syndromes...
Villagran-Garcia and al. The link between paraneoplastic neurological syndromes (PNS) and renal cell and bladder cancer (RCC/BC) is rare and uncertain. Our aim was to clinically evaluate, in light of the updated PNS criteria, these uncommon associations.
August 2022 - Review: Sensory neuronopathies....
Pr Antoine includes recent findings in the strategy of the cause regarding the diagnostic of SNN relies on criteria distinguishing SNN from other neuropathies.
August 2022 - Review: Cytokine dynamics and targeted...
Ciano Petersen and al. summarize the current knowledge about the role of cytokines in the pathogenesis of autoimmune encephalitis, combining theoretical analysis with experimental validations, to assess their suitability as clinical biomarkers
July 2022 - Article: Immune and Genetic Signatures of Breast....
Peter E and al. aimed to identify the tumors’ genetic and immune specificities involved in Yo-PCD pathogenesis.
January 2022 - Review: Novelties in Autoimmune and Paraneoplastic Cerebellar...
Dr Muñiz Castrillo and al review the principal novelties of the last 20 years regarding autoimmune and paraneoplastic cerebellar ataxias.
January 2022 - Review: Immunomodulation in the acute phase of autoimmune encephalitis
Ciano-Petersen and al. propose in this review to clarify the diagnostic and therapeutic approach during the acute phase, i.e. during the first weeks or months after symptom onset, of patients with AE and related disorders.
January 2022 - Article: Core cerebrospinal fluid biomarker profile...
Lardeux and al. compare CSF biomarkers’ levels in patients suffering from anti-Leucine-rich Glioma-Inactivated 1 (LGI1) encephalitis to neurodegenerative [Alzheimer’s disease (AD), Creutzfeldt–Jakob’s disease (CJD)] and primary psychiatric (PSY) disorders.
November 2021 - Article: How to diagnose and manage....
Vogrig and al. provide an update of the recent advances in the diagnosis and management of neurological toxicities related to ICI use.
November 2021 - Article: Anti-FGFR3 antibody epitopes are functional...
Tholance and al. identifed the epitope(s) of anti-FGFR3 autoantibodies and potential epitope-dependent clinical subtypes screening 68 anti-FGFR3-positive patients and 35 healthy controls.
November 2021 - Review: Role of LGI1 protein in synaptic transmission...
In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss the effects of LGI1 on neuronal excitability and synaptic transmission in physiological and pathological conditions
September 2021 - Article: Immunopathogenesis and proposed clinical...
Vogrig and al. describe the mechanisms of spontaneous cancer regression and concomitant development of encephalitis regarding KLHL11-Ab syndromes and proose a new score for diagnosis (MATCH).
Agust 2021 - Article: Argonaute Autoantibodies as Biomarkers
Do and al identified and characterized Argonote antibodies as novel biomarkers for patients with central and peripheral neurologic diseases.
June 2021 - Review: Fundamental mechanistic....
This review summarizes key mechanistic insights into three such rare but paradigmatic neuroimmunological diseases.
May 2021- Article: Updated Diagnostic Criteria for Paraneoplastic...
This article presents the updated diagnostic criteria for paraneoplastic neurologic syndromes. A collaborative effort from 19 experts from 8 coutries to enhance the clinical care of patients and to encourage standardization of PNS research initiatives.
April 2021 - Article: Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis...
This paper proposes a description of (still rare) anti-AK5 encephalitis: predominantly older men with episodic amnesia and depression, prominent weight loss/anorexia, progressive atrophy, poor response to immunotherapy, strong HLA association and likely T cell-mediated pathogenesis.
March 2021 - Article: Clinical and Prognostic Value of Immunogenetic...
Muñiz-Castrillo and al. aimed to investigate whether clinical or immunologic differences exist among patients with anti-LGI1 LE according to CSF positivity for LGI1-Abs and HLA-DRB1*07:01 carrier status.
Februrary 2021 - Article: Familial autoimmunity in neurological patients with GAD65...
New article from Dr Muñiz-Castrillo and al. These results suggest a heterogeneous genetic predisposition to GAD65 neurological disorders, possibly involving multiple loci and modes of inheritance with different contribution in each family.
January 2021 - Article: CIDP antibodies target junction proteins...
Moritz and al. proposes systemic characteristics in the repertoires of targeted autoantigens in chronic inflammatory demyelinating polyneuropathy (CIDP).
December 2020 - Article: Cranial nerve disorders associated...
This paper from Vogrig and al. describes the spectrum, treatment, and outcome of cranial nerve disorders associated with immune checkpoint inhibitors.
October 2020 - Article: Proper definition of the set of autoantibody...
For autoimmune-related diseases, a novel approach systemically analyzes entire antibody sets in an omics-like manner. How to properly define these sets has been shown by Moritz and al.
August 2020 - Article: Diagnostic des encéphalites auto-immunes
This article from Muñiz-Castrillo and al. briefly review the clinical presentation and the ancillary tests leading to a probable or definite diagnosis, which is the first step towards adequate management of these patients.
August 2020 - Article: Epidemiology of paraneoplastic neurologic syndromes...
Hébert and al report the observed and expected incidence rates of paraneoplastic neurologic syndromes (PNSs) and autoimmune encephalitides (AEs) diagnosed in France between 2016 and 2018 using a population-based epidemiologic study.
July 2020 - Article: Anti-CASPR2 clinical phenotypes correlate...
In this paper, Dr Muñiz-Castrillo and al. present some physiopathological clues by studying whether the immunological and genetic (HLA) characteristics differed according to the clinical phenotypes.
July 2020 - Review: Fundamental mechanisms of autoantibody-induced...
This review's aim is to evaluate what kind of cerebellar ion channels, their related proteins, and the synaptic machinery proteins that are preferably impaired by autoantibodies so as to develop cerebellar ataxias (CAs).
June 2020 - Article: Transient neurological symptoms preceding...
Pr Honnorat team describes a transient clinical features preceding immune-mediated CA with GAD-Abs, in order to provide clues for an early diagnosis.
June 2020 - Article: Central nervous system complications associates...
This article describes the spectrum and outcome of central nervous system complications associated with immune checkpoint inhibitors (CNS-ICI).
June 2020 - Review: Pathophysiology of paraneoplastic autoimmune...
Pr Honnorat team provides a comprehensive review of the most recent findings in the field of PNSs and AEs, with particular focus on their triggering factors and immunopathogenesis.
June 2020 - Review: Immunological bases of paraneoplastic cerebellar...
Pr Liblau's team review recent literature pertaining to the pathophysiology of PCD and propose an immune scheme underlying this disabling disease.
May 2020 - Article: Clinical spectrum and diagnostic pitfalls of neurologic...
In this article are presented the descritption of the main syndrome and clinical course in a large cohort of patients with anti–Ri-associated paraneoplastic neurologic syndrome (Ri-PNS).
May 2020 - Letter: Anti-Hu associated paraneoplastic syndromes triggered...
This article provides the description of two patients with SCLC treated with ICIs who developed sensory neuronopathy (Case 1) and cerebellar degeneration (Case 2) in association with Hu-Abs.
May 2020 - Letter: Value of onconeuronal antibodies in checkpoint...
Vogrig and al. expose their disagreement about statements made by Dubey and al concerning patients with n‐irAEs.
March 2020 - Article: Long-term outcomes in temporal lobe epilepsy..
This article proposes to assess the long-term outcomes of patients with temporal lobe epilepsy and CSF anti-glutamate decarboxylase antibodies (GAD65-Abs).
March 2020 - Article: Primary DQ effect in the association between...
Muñiz-Castrillo and al. present a study which fully describe the HLA haplotypes present in patients with neurological syndromes with GAD65-Ab and establish whether differences in HLA profiles exist according to the neurological clinical presentation or the co-occurrence of other organ-specific autoimmune diseases.
March 2020 - Article: Diagnostic yield of commercial immunodots to....
This paper proposes to investigate the diagnostic yield of commercial immunodots to detect onconeural antibodies associated with paraneoplastic neurologic syndromes (PNSs), we analyzed the proportion of confirmed positive results using alternative techniques.
January 2020 - Article: Epidemiology of paraneoplastic neurological...
This paper presents the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy.
January 2020 - Review: Association between HLA and autoimmune...
Muñiz-Castrillo and al. report the main alleles and haplotypes, and discuss the clinical and pathogenic implications of these findings.
